Lash serums can cause prolonged redness of the eyelid margin (around the eye lashes) - this is usually inflammation or irritation caused by the serum sensitising the skin. If you do notice this, I would really recommend stopping use as it could turn into a nasty reaction which, ironically, could damage the eyelash hair follicles and cause permanent lash loss.
Lash serums which use prostaglandin analogues have been reported to cause darkening of the eyelid skin, although you can manage this risk by not using the product for longer than it was intended (eg a maximum of 12 weeks).
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